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December 2014

From original research in 2014…………

1. Progesterone may have neuroprotective effects on the brain but the administration of parenteral progesterone does not help patients with traumatic brain injuries. (Article)

2. In autosomal dominant polycystic kidney disease keeping the systolic blood pressure at 110mm Hg or lower is better for preserving renal function than keeping the blood pressure at what is usually considered normal. (Article)

3. Dual antiplatelet therapy can be recommended for 30 months after insertion of a drug eluting coronary stent even though there is an increased risk of bleeding. (Article)

4. There is a variant of non-small cell lung cancer that occurs in those who are not smokers. This cancer carries a gene called ALK. A drug called crizotinib inhibits this gene and may be effective for this type of cancer. (Article)

5. Patient who need to undergo CABG may also have some degree of mitral regurgitation. Does it help to repair the mitral valve too while undergoing CABG? This trial says that if the mitral regurgitation is not severe, repairing the valve at the time of CABG does not confer any obvious advantage in the short term. (Article)

6. Apoprotein C3 (Apo C3) is a small protein molecule found associated with chylomicrons (and other lipid molecules). In those who have familial chylomicronemia (a condition with dangerously high triglyceride levels of more than 10mmol/L), a drug that targets the synthesis of ApoC3 may be effective in reducing these high triglyceride levels. (Article)


Dr Vela Menon, MD
Clinical Associate Professor of Medicine
International Medical University, Malaysia

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